Bruce D Wyse Selected Research

WL 19

10/2013	A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.
5/2013	Small molecule angiotensin II type 2 receptor (AT₂R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats.

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Bruce D Wyse Research Topics

Disease

9	Neuralgia (Stump Neuralgia) 09/2015 - 03/2011
8	Pain (Aches) 01/2019 - 06/2012
6	Hyperalgesia 12/2014 - 07/2006
3	Diabetic Neuropathies (Diabetic Neuropathy) 09/2015 - 03/2011
3	Constipation 04/2013 - 01/2012
2	Hypersensitivity (Allergy) 01/2014 - 05/2013
2	Prostatic Neoplasms (Prostate Cancer) 01/2014 - 05/2013
2	Hyperglycemia 05/2011 - 03/2011
2	Inflammation (Inflammations) 07/2008 - 07/2006
1	Hypotension (Low Blood Pressure) 09/2015
1	Peripheral Nervous System Diseases (PNS Diseases) 12/2014
1	Wounds and Injuries (Trauma) 04/2014
1	Polyneuropathies (Polyneuropathy) 04/2014
1	Respiratory Insufficiency (Respiratory Failure) 04/2014
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2011
1	Prediabetic State (Prediabetes) 03/2011
1	Type 2 Diabetes Mellitus (MODY) 03/2011

Drug/Important Bio-Agent (IBA)

8	Analgesics (Analgesic Drugs)IBA 09/2015 - 05/2013
7	Morphine (MS Contin)FDA LinkGeneric 01/2019 - 03/2011
4	Opioid Analgesics (Opioids)IBA 07/2015 - 03/2011
4	Type 2 Angiotensin ReceptorIBA 04/2014 - 05/2013
3	Type 1 Angiotensin ReceptorIBA 04/2014 - 10/2013
3	Opioid Receptors (Opioid Receptor)IBA 04/2013 - 07/2006
2	1,2,5-oxadiazole 2-oxideIBA 01/2019 - 09/2015
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 09/2015
2	PD 123319IBA 01/2014 - 05/2013
2	WL 19IBA 10/2013 - 05/2013
1	Nitric Oxide DonorsIBA 09/2015
1	Oxycodone (Oxycontin)FDA LinkGeneric 07/2015
1	alpha-tocopherol phosphateIBA 07/2015
1	Cisplatin (Platino)FDA LinkGeneric 12/2014
1	Angiotensin II Type 2 Receptor BlockersIBA 04/2014
1	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 10/2013
1	Angiotensin IIIBA 10/2013
1	p38 Mitogen-Activated Protein KinasesIBA 10/2013
1	Gabapentin (Neurontin)FDA LinkGeneric 05/2013
1	EMA400IBA 05/2013
1	Meloxicam (Mobic)FDA LinkGeneric 05/2013
1	Naloxone (Narcan)FDA LinkGeneric 05/2013
1	Narcotic Antagonists (Opioid Antagonists)IBA 05/2013
1	Amitriptyline (Elavil)FDA LinkGeneric 05/2013
1	Peptides (Polypeptides)IBA 04/2013
1	Streptozocin (Streptozotocin)FDA Link 05/2011
1	Insulin (Novolin)FDA Link 05/2011
1	Blood Glucose (Blood Sugar)IBA 03/2011
1	GTP-Binding Proteins (G-Protein)IBA 03/2011
1	mu Opioid Receptors (mu Opioid Receptor)IBA 07/2008
1	Capsaicin (Zostrix)FDA Link 05/2008
1	Ion Channels (Ion Channel)IBA 05/2008
1	CalciumIBA 05/2008
1	TRPV Cation ChannelsIBA 07/2006

Therapy/Procedure

5	Analgesia 09/2015 - 03/2011
2	Oral Administration 07/2015 - 06/2012
2	Intravenous Administration 04/2013 - 06/2012
1	Drug Therapy (Chemotherapy) 12/2014
1	Euthanasia (Mercy Killing) 05/2013
1	Glycemic Control 05/2011